| ACTIVE | PLAYER | TITLES |
|---|---|---|
| John Isner | 2 | |
| A | Pablo Carreño Busta | 1 |
| A | Roberto Bautista Agut | 1 |
| A | Daniil Medvedev | 1 |
| A | Hubert Hurkacz | 1 |
| A | Ilya Ivashka | 1 |
| A | Adrian Mannarino | 1 |
| A | Sebastián Báez | 1 |
| A | Lorenzo Sonego | 1 |
| Jürgen Melzer | 1 | |
| Lukáš Rosol | 1 | |
| Kevin Anderson | 1 |
Table: From 2011 onward, List of Most Winston Salem Open titles, ATP 250, United States Of America, Men, Tennis, Ranked.