| ACTIVE | PLAYER | TITLES |
|---|---|---|
| A | Petra Kvitová | 3 |
| Serena Williams | 2 | |
| Simona Halep | 2 | |
| A | Aryna Sabalenka | 2 |
| Dinara Safina | 1 | |
| A | Aravane Rezaï | 1 |
| Maria Sharapova | 1 | |
| Kiki Bertens | 1 | |
| A | Ons Jabeur | 1 |
| A | Iga Świątek | 1 |
Table: From 2009 onward, List of Most Mutua Madrid Open Titles, WTA 1000 Women, Spain, Tennis, Ranked.