| ACTIVE | PLAYER | TITLES |
|---|---|---|
| A | Taylor Fritz | 2 |
| Ernests Gulbis | 2 | |
| Xavier Malisse | 2 | |
| Jan-Michael Gambill | 2 | |
| Jason Stoltenberg | 2 | |
| A | Miomir Kecmanovic | 1 |
| A | Cameron Norrie | 1 |
| A | Hubert Hurkacz | 1 |
| A | Reilly Opelka | 1 |
| A | Radu Albot | 1 |
| A | Frances Tiafoe | 1 |
| A | Marin Čilić | 1 |
| Jack Sock | 1 | |
| Sam Querrey | 1 | |
| Ivo Karlović | 1 | |
| Kevin Anderson | 1 | |
| Juan Martín del Potro | 1 | |
| Mardy Fish | 1 | |
| Kei Nishikori | 1 | |
| Tommy Haas | 1 | |
| Ricardo Mello | 1 | |
| Davide Sanguinetti | 1 | |
| Stefan Koubek | 1 | |
| Lleyton Hewitt | 1 | |
| Andrew Ilie | 1 | |
| Todd Woodbridge | 1 | |
| Luiz Mattar | 1 | |
| Todd Martin | 1 |
Table: From 1993 onward, List of Most Delray Beach Open titles, ATP 250, United States of America, Men, Tennis, Ranked.