| ACTIVE | PLAYER | TITLES |
|---|---|---|
| Justine Henin | 2 | |
| Tamarine Tanasugarn | 2 | |
| Coco Vandeweghe | 2 | |
| A | Ekaterina Alexandrova | 2 |
| A | Elise Mertens (Current) | 1 |
| Anke Huber | 1 | |
| Ruxandra Dragomir | 1 | |
| Julie Halard-Decugis | 1 | |
| Kristina Brandi | 1 | |
| Martina Hingis | 1 | |
| Eleni Daniilidou | 1 | |
| Kim Clijsters | 1 | |
| Mary Pierce | 1 | |
| Klára Koukalová | 1 | |
| A | Michaëlla Krajicek | 1 |
| Anna Chakvetadze | 1 | |
| Roberta Vinci | 1 | |
| Nadia Petrova | 1 | |
| Simona Halep | 1 | |
| Camila Giorgi | 1 | |
| Anett Kontaveit | 1 | |
| A | Aleksandra Krunić | 1 |
| A | Alison Riske | 1 |
| A | Liudmila Samsonova | 1 |
Table: From 1996 onward, Most Libéma Open Titles (Women), WTA 250, ‘s-Hertogenbosch, Netherlands, Tennis, Ranked.