| ACTIVE | PLAYER | TITLES |
|---|---|---|
| Chris Evert | 8 | |
| Martina Navratilova | 4 | |
| Steffi Graf | 4 | |
| Serena Williams | 3 | |
| A | Jessica Pegula (Active) | 2 |
| Tracy Austin | 2 | |
| Gabriela Sabatini | 2 | |
| Conchita Martínez | 2 | |
| Martina Hingis | 2 | |
| Justine Henin | 2 | |
| Rosemary Casals | 1 | |
| Arantxa Sánchez Vicario | 1 | |
| Amanda Coetzer | 1 | |
| Mary Pierce | 1 | |
| Jennifer Capriati | 1 | |
| Iva Majoli | 1 | |
| Venus Williams | 1 | |
| Nadia Petrova | 1 | |
| Jelena Janković | 1 | |
| Sabine Lisicki | 1 | |
| Samantha Stosur | 1 | |
| A | Caroline Wozniacki | 1 |
| Andrea Petkovic | 1 | |
| Angelique Kerber | 1 | |
| A | Sloane Stephens | 1 |
| A | Daria Kasatkina | 1 |
| Kiki Bertens | 1 | |
| A | Madison Keys | 1 |
| A | Veronika Kudermetova | 1 |
| A | Belinda Bencic | 1 |
| A | Ons Jabeur | 1 |
| A | Danielle Collins | 1 |
Table: From 1973 onward, Most Most Credit One Charleston Open Titles, WTA 500, United States of America, Women, Tennis, Ranked.