| ACTIVE | PLAYER | TITLES |
|---|---|---|
| Jimmy Connors | 4 | |
| Andy Roddick | 3 | |
| Manuel Orantes | 3 | |
| Steve Johnson | 2 | |
| Juan Mónaco | 2 | |
| Andre Agassi | 2 | |
| Andrés Gómez | 2 | |
| José Luis Clerc | 2 | |
| Željko Franulović | 2 | |
| A | Ben Shelton | 1 |
| A | Frances Tiafoe | 1 |
| A | Cristian Garín | 1 |
| A | Reilly Opelka | 1 |
| Mardy Fish | 1 | |
| Ivo Karlović | 1 | |
| Marcel Granollers | 1 | |
| Lleyton Hewitt | 1 | |
| Juan Ignacio Chela | 1 | |
| Ryan Sweeting | 1 | |
| John Isner | 1 | |
| Fernando Verdasco | 1 | |
| Jack Sock | 1 | |
| Tommy Haas | 1 | |
| Mats Wilander | 1 | |
| Jay Berger | 1 | |
| David Wheaton | 1 | |
| Jaime Yzaga | 1 | |
| MaliVai Washington | 1 | |
| Horacio de la Peña | 1 | |
| Jason Stoltenberg | 1 | |
| Thomas Enqvist | 1 | |
| Fernando Meligeni | 1 | |
| Michael Chang | 1 | |
| Jim Courier | 1 | |
| Magnus Norman | 1 | |
| Fernando González | 1 | |
| José Higueras | 1 | |
| Jimmy Arias | 1 | |
| Ivan Lendl | 1 | |
| Bob Hewitt | 1 | |
| Clark Graebner | 1 | |
| Cliff Richey | 1 |
Table: From 1968 onward, List of Most Fayez Sarofim & Co. U.S. Men’s Clay Court Championship, Houston Open, ATP 250, United States of America, Tennis, Ranked.